Assuming that you start as a premium character or that you intend to become premium around the time you become a priest, it is important to raise your Strength characteristic to at least 21 before you become a priest, since most priest penalties affect skills that raise strength well.
When you become a priest you must raise your soul strength/depth in order to improve the outcome of your spells. Libilian and Magranon priests must raise [soul strength], Fo and Vynoran Priests must raise [soul depth].
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